Nahit RIZANER

Assoc. Prof. Dr. NAHİT RIZANER

Faculty of Medicine

E-mail nrizaner@ciu.edu.tr
Telephone number +90 392 671 11 11
Extension 2427
Office ST204
Other information

U.N. Sustaınable Development Goals


Good health and well-being

CURRICULUM VITAE

Education
  • Imperial College London Science, Technology and Medicine (PhD, 2011)
  • University of Glasgow Bioinformatics (Master, 2004)
  • Istanbul Universitesi Biology (Molecular Biology and Genetics) (Undergraduate, 2002)
Publications

Articles published in peer reviewed international journals (SCI,SSCI,Arts and Humanities)

  • Rizaner N, Fraser SP, Gul IB, Purut E, Djamgoz MBA, Altun S. Lidocaine Inhibits Rat Prostate Cancer Cell Invasiveness and Voltage-Gated Sodium Channel Expression in Plasma Membrane. J Membr Biol. 2024 Apr;257(1-2):17-24. doi: 10.1007/s00232-023-00302-z. Epub 2024 Jan 2. PMID: 38165418. - 2024
  • Umar H, Rizaner N, Usman AG, Aliyu MR, Adun H, Ghali UM, Uzun Ozsahin D, Abba SI. Prediction of Cell Migration in MDA-MB 231 and MCF-7 Human Breast Cancer Cells Treated with Albizia Lebbeck Methanolic Extract Using Multilinear Regression and Artificial Intelligence-Based Models. Pharmaceuticals (Bas - 2023
  • Alıcı YH, Oztoprak H, Rizaner N, Baskak B, Ozguven HD. (2022) Deep Neural Network to Differentiate Brain Activity Between Patients with Euthymic Bipolar Disorders and Healthy Controls During Verbal Fluency Performance: A Multichannel Near-Infrared Spectroscopy Study. Psychiatry Res Neuroimaging. Available online 28 August 2022, 111537 - 2022
  • Kavaz D, Abubakar AL, Rizaner N, Umar H. (2021) Biosynthesized ZnO Nanoparticles Using Albizia lebbeck Extract Induced Biochemical and Morphological Alterations in Wistar Rats. Molecules. 26(13):3864. - 2021
  • Beyaz H, Uludag H, Kavaz D, Rizaner N. (2021) Mechanisms of Drug Resistance and Use of Nanoparticle Delivery to Overcome Resistance in Breast Cancers. Adv Exp Med Biol. 1347:163-181. - 2021
  • Rizaner N, Uzun S, Fraser SP, Altun S & Djamgoz MB. (2020). Riluzole: Anti-invasive effects on rat prostate cancer cells under normoxic and hypoxic conditions. Basic Clin Pharmacol Toxicol. 127(4):254-264. - 2020
  • Umar H, Kavaz D, Rizaner N. (2018) Biosynthesis of zinc oxide nanoparticles using Albizia lebbeck stem bark, and evaluation of its antimicrobial, antioxidant, and cytotoxic activities on human breast cancer cell lines. Int J Nanomedicine.14:87-100. - 2018
  • Isbilen O, Rizaner N, Volkan E. (2018) Anti-proliferative and cytotoxic activities of Allium autumnale P. H. Davis (Amaryllidaceae) on human breast cancer cell lines MCF-7 and MDA-MB-231. BMC Complement Altern Med. 18(1):30. doi: 10.1186/s12906-018-2105-0. - 2018
  • Rizaner N, Onkal R, Fraser SP, Pristerá A, Okuze K & Djamgoz MBA. (2016) Intracellular calcium oscillations in strongly metastatic human breast and prostate cancer cells: control by voltage-gated sodium channel activity. Eur Biophys J. 45:735'748 - 2016
  • Tetik S, Kiliç A, Aksoy H, Rizaner N, Ahmad S & Yardimci T. (2015) Oxidative stress causes plasma protein modification. Indian J Exp Biol. 53(1): 25-30. - 2015
  • Mazurek MP, Prasad PD, Gopal E, Fraser SP, Bolt L, Rizaner N, Palmer CP, Foster CS, Palmieri F, Ganapathy V, Stühmer W, Djamgoz MBA & Mycielska ME (2010). Molecular origin of plasma membrane citrate transporter in human prostate epithelial cells. EMBO Rep. 11: 431-7. - 2010
  • Mazurek MP, Prasad PD, Gopal E, Fraser SP, Bolt L, Rizaner N, Palmer CP, Foster CS, Palmieri F, Ganapathy V, Stühmer W, Djamgoz MBA & Mycielska ME (2010). Molecular origin of plasma membrane citrate transporter in human prostate epithelial cells. EMBO Rep. 11: 431-7. - 2010

Books and books chapters published internationally

  • Umar H, Idris M, Kavaz D, Ghali UM, Usman AG, Rizaner N. (2022) Nanoencapsulation of nutraceuticals and dietary supplements for effective delivery. Applications of Nanotechnology in Drug Discovery and Delivery (ISBN: 978-0-12-824408-1). - 2022

Other Publications

  • Rizaner N, Uzun S, Fraser SP, Altun S, Djamgoz MBA. Rilızole: Anti-invasive effect of a Voltage-Gated Sodium Channel Blocker on Rat Prostate Cancer Cells. Uluslararası 2. İyon Kanalları ve Kanser Sempozyumu 23 September 2019, İzmir, Turkey. - 2019
  • Rizaner N. (2016) Voltaj Kapılı Sodyum Kanalı ve Kanser. Kıbrıs Bilim ve Teknoloji Dergisi. (Haziran) - 2016

Papers presented in National conferences and printed as proceedings

  • . N Rizaner, R Onkal, SP Fraser, M Djamgoz (2018) Involvement of Intracellular Ca2+ Stores in Spontaneous Ca2+ Oscillations in a Human Strongly Metastatic Prostate Cancer Cell. Acta Physiol. 225: 52-52. (Conference proceeding). - 2018
  • Rizaner N. Biyoetik: Güncel Tıbbi Araştırmalar ve Problemler. II. Sağlık Hukuku Sempozyumu 30 March 2017, Nicosia, North Cyprus. (Nicosia, Cyprus, 2017) - 2017
  • Rizaner N. Cancer Pathophysiology. European Pharmaceutical Students Association TWINNET Workshop, 17-20 May 2016 Nicosia, North Cyprus. - 2016
  • Rizaner N, Onkal R, Fraser SP, Djamgoz MB. Intracellular calcium oscillations in strongly metastatic human breast and prostate cancer cells: Control by voltage-gated sodium channel activity. 1st Winter Data Retreat of EMU Genetics Club, 29 January 2016, Famagusta, North Cyprus. - 2016
  • Rizaner N, Onkal R, Fraser SP, Djamgoz MB. Güçlü Metastatik İnsan Meme ve Prostat Kanseri Hücrelerindeki Kalsiyum Osilasyonları: Voltaj-kapılı Sodyum Kanalı Aktivitesi ile Kontrol. İyon kanalları ve Kanser Sempozyumu, 29 May 2014, Istanbul, Turkey. - 2014
  • Rizaner N, Onkal R, Fraser SP, Djamgoz MB. Spontaneous intracellular calcium oscillations in strongly metastatic human breast and prostate cancer cells.1st EMU Genomics and Proteomics Research Meeting, 21 November 2014, Famagusta, North Cyprus. - 2014
  • Rizaner N, Onkal R, Fraser SP, Djamgoz MB. Effects of long-term hypoxia on voltage-gated Na channel expression and metastatic cell behaviours in rat prostate cancer. 23. Ulusal Biyokimya Kongresi, 29 November ' 2 December 2011, Adana. - 2011

Articles published in National journals

  • Djamgoz MBA, Akun E, Arslan B, Onbasi R, Nazif S, Besler HT & Rizaner N. (2017) Cancer in North Cyprus: 1. Current Status, an Overview. Cyprus J Med Sci. 2: 9-12 - 2017
  • Djamgoz MBA, Akun E, Arslan B, Onbasi R, Volkan E, Isbilen O, Kavaz D & Rizaner N. (2017) Cancer in North Cyprus: 2. Biomedical Research Activities. Cyprus J Med Sci. 2:13-18 - 2017
  • Tetik S, Ozaltun K, Ozakpınar O, Disbudak M, Rizaner N, Yavuz S & Yardimcı KT. (2011) In vivo effect of colchicine, colchici and snti-aggregating agent on protein oxidation in Behcet's Disease. Cumhuriyet Med J. 33: 435-42. - 2011

Papers presented in international conferences and printed as proceedings

  • Rizaner N, Onkal R, Fraser SP, Djamgoz MB. Effects of long-term hypoxia on voltage-gated Na channel expression and metastatic cell behaviours in rat prostate cancer. An International Meeting on Ion Channels, Transporters & Cancer 2015, 9-10 September 2015, London, UK. - 2015
  • Rizaner N, Keun H, Mycielska ME, Djamgoz MB. Citrate transport in strongly metastatic human prostate cancer (PC-3M) cells: control by voltage-gated sodium channel activity. The first colloquium on 'Ion Channels and Cancer', 25 - 28 November 2007, the Schloss Ringberg, Tegernsee, Germany - 2007
  • Rizaner N. 'Citrate transport mechanisms in human prostate epithelial cells', London Prostate Interest Group Meeting, 11 September, 2007, London, U.K. - 2007
Thesis Supervision

Master Thesis Supervised

  • The effect of Vernonia amygdalina plant extract on breast cancer cell models. Biotechnology Research Centre, Cyprus International University, 2016-2017 - 2017
  • Phytochemical screening, antimetastatic and antibacterial activities of Momordica balsamina leaf extracts. Biotechnology Research Centre, Cyprus International University, 2015-2016 - 2016
  • Anti-metastatic activity of Albizia lebbeck Steam Bark Extract Against Breast Cancer Cell. Biotechnology Research Centre, Cyprus International University, 2015-2016 - 2016
Projects
  • The Effect of VGSC (nNAV1.5) INaP Blocker Eleclazine on Breast Cancer. KAV Project, Biotechnology Research Centre, Cyprus International University, 2018
  • Breast Cancer MDA-MB-231 Cell Model: Enhancement of Metastatic Cell Behaviours by Hypoxia and Assessment of the Role of Functional Voltage-Gated Sodium Channel Expression, TÜBİTAK, 1001 - Bilimsel ve Teknolojik Araştırma Projelerini Destekleme Pr., Biotechnology Research Centre, Cyprus International University, 2013- 2017
  • Effects of Legionella pneumophila and its bacterial products on Breast Cancer Cell model. Biotechnology Research Centre, Cyprus International University, 2015-
  • Arsenic Distribution in Soils and Waters in Omorfo Region of TRNC, KAV, Biotechnology Research Centre, Cyprus International University, 2015-
  • The effect of Vernonia amygdalina plant extract on breast cancer cell models. Biotechnology Research Centre, Cyprus International University, 2016-2017
  • Phytochemical screening, antimetastatic and antibacterial activities of Momordica balsamina leaf extracts. Biotechnology Research Centre, Cyprus International University, 2015-2016
  • Anti-metastatic activity of Albizia lebbeck Steam Bark Extract Against Breast Cancer Cell. Biotechnology Research Centre, Cyprus International University, 2015-2016
  • Arsenic Distribution in TRNC Soils and Waters Preliminary Study, KAV, Biotechnology Research Centre, Cyprus International University, 2013'2014
  • Toxicity, adhesion and invasion of highly and lowly metastatic human breast cancer cells by uropathogenic E.coli UTI-89 strain. DRD2015, Biotechnology Research Centre, Cyprus International University, 2013'2015
  • Study of ionic mechanisms in model cell lines of prostate cancer. Pro Cancer Research Fund (PCRF), Imperial College London, UK, 2006-2011
  • Citrate transport in plasma membrane of normal human prostate epithelial cells. The Wellcome Trust, Imperial College London, UK, 2007-2010.
  • New tools for biological microarray analysis. Bioinformatics Research Center, University of Glasgow, 2004.
Administrative Duties
  • Head of Cancer Laboratories, Biotechnology Research Centre, Cyprus International University. (Since 2011); (2011-ONGOING)
  • Coordinator of Biotechnology Research Centre, Cyprus International University (2011-2014) (2011-2014)
  • Director of Biotechnology Research Centre, Cyprus International University (Since 2014); (2014-ONGOING)
  • Member of Purchase Comity, Cyprus International University (2015-2019)
  • Head of Department, Bioengineering (2023-ONGOING)